Despite the progress in contraceptives, there is still a high rate of unintended pregnancy all over the world, due largely to the lack of effective, convenient and safe birth control methods. Compared with short-acting contraceptives, approaches that can offer long-term pregnancy protection attract more interest because of the reduced dosing frequency and improved patient compliance. As a novel transdermal drug delivery system, MN patch has been widely used for a variety of biomedical applications, including long-acting contraception, owning to the unique properties, such as enabling self-administration, avoiding pain and eliminating biohazardous waste. In this review, we provide a systemic review of MN patches that have been utilized for long-term contraception, including dissolvable MN patches, polymeric biodegradable MN patches and silk fibroin-based biodegradable MN patches. The acceptability and biosafety of these contraceptive MN patches are also discussed. Finally, we give our perspectives on the future clinical translation of MN patches for long-acting contraception.