The Organoid Models for Chinese Herbal Medicine Studies
# contributed equally to this work, * Corresponding author
Abstract
Organoids are the aggregation of three-dimensional cells generated from pluripotent stem cells or adult stem cells in vitro. With many advantages over cell models and animal models, organoids have gradually been used in drug and clinical medical research in recent years. Chinese herbal medicine (CHM) is characterized by its multi-target and multi-pathway treatment method; however, there is no commonly accepted study method regarding its efficacy and mechanism. In this review, we summarize the important applications of organoid models in pharmacodynamic mechanism study, efficacy and safety evaluation and personalized medicine of CHM, providing with the theoretical basis for its development and innovation.
- 17 Feb 2023 17:53 Version 1
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