Recent advances in nano-targeting drug delivery system for rheumatoid arthritis treatment

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Hanmei Li# Key Laboratory of Coarse Cereal Processing (Ministry of Agriculture and Rural Affairs), School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China

Rui Gou# School of Mechanical Engineering, Chengdu University, Chengdu 610106, China

Jiaying Liao Key Laboratory of Coarse Cereal Processing (Ministry of Agriculture and Rural Affairs), School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China

Yao Wang Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu 610106, China

Rui Qu Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu 610106, China

Qi Tang Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu 610106, China++State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China

Jingyao Gan Department of Pharmaceutical Sciences and the Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA

Liang Zou* Key Laboratory of Coarse Cereal Processing (Ministry of Agriculture and Rural Affairs), School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China

Sanjun Shi* State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China

# contributed equally to this work


Abstract

Rheumatoid arthritis is a systemic inflammatory disease that can lead to articular cartilage destruction and periarticular bone erosion, which ultimately compromise joint integrity and function. Anti-inflammatory drugs and biological agents are commonly used to treat RA, but they cannot selectively target inflamed joints due to their systemic mechanism, short half-life, and low bioavailability. Therefore, these agents must be used at high doses that are delivered frequently, which increases costs and the risk of side effects. Drug delivery systems, such as nanoparticles, liposomes and micelles can significantly prolong drug half-life in the body and targeting delivery them into the joints. In this review, we introduce the pathogenesis and clinical diagnosis of rheumatoid arthritis comprehensively, and summarize the recent advances in targeted therapeutic strategies especially nano-targeting systems for rheumatoid arthritis.

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  • 13 Jan 2023 10:53 Version 1
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