Detection Technology and Clinical Applications of Serum Virological Products of Hepatitis B Virus (HBV) Infection

Preprint | 
10.55415/deep-2023-0043.v1
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Ying Liu#
Zhengzhou University
Zhengzhou University
Di Wu#
Zhengzhou University
Zhengzhou University
Kui Zhang
Southwest University
Southwest University
Liping Chen
Fudan University
Fudan University
Shuya Zhang
Zhengzhou University
Zhengzhou University
YuXuan Liu
Zhengzhou University
Zhengzhou University
Jilin Cheng
Fudan University
Fudan University
Jun Huang*
Zhengzhou University
Zhengzhou University

# contributed equally to this work, * Corresponding author


Abstract

Serum virological products of hepatitis B virus (HBV) infection, such as HBV DNA, HBV RNA, hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), and hepatitis B core-related antigen (HBcrAg), are important non-invasive indicators that are critical for the rapid diagnosis of the diseases. Improving the accuracy of these products is essential, and the development of corresponding detection technologies is pivotal in achieving this goal. The aim of this article is to provide a comprehensive and systematic overview of the life cycle of HBV, including the latest research progress. In addition, classical and novel methods for detecting HBV serum virological products with high accuracy are analyzed and compared, and their clinical applications are discussed. Ultimately, the goal of this article is to provide valuable insights and references for effectively monitoring chronic hepatitis B (CHB) infection.

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  • 24 Jun 2023 10:37 Version 1
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