Susceptibilities of Yersinia pestis to twelve antimicrobial agents in China

Preprint | 
10.55415/deep-2022-0037.v3
This is not the most recent version. There is anewer versionof this content available.
Jian He#
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Xiaoyan Yang#
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Juan Jin#
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Yiting Wang
National Institute for Communicable Disease Control and Prevention (ICDC), China CDC, Changping, Beijing, China.++State Key Laboratory of Infectious Disease Prevention and Control. Beijing, China
National Institute for Communicable Disease Control and Prevention (ICDC), China CDC, Changping, Beijing, China.++State Key Laboratory of Infectious Disease Prevention and Control. Beijing, China
Sheng Li
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Qi Zhang
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Yumeng Wang
National Institute for Communicable Disease Control and Prevention (ICDC), China CDC, Changping, Beijing, China.++State Key Laboratory of Infectious Disease Prevention and Control. Beijing, China
National Institute for Communicable Disease Control and Prevention (ICDC), China CDC, Changping, Beijing, China.++State Key Laboratory of Infectious Disease Prevention and Control. Beijing, China
Hailian Wu
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Jixiang Bai
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Haomin Xiong
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Yong Jin
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Juan Li
National Institute for Communicable Disease Control and Prevention (ICDC), China CDC, Changping, Beijing, China.++State Key Laboratory of Infectious Disease Prevention and Control. Beijing, China
National Institute for Communicable Disease Control and Prevention (ICDC), China CDC, Changping, Beijing, China.++State Key Laboratory of Infectious Disease Prevention and Control. Beijing, China
Xuefei Zhang
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Ruixia Dai*
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Qinghai Institute for Endemic Disease Control and Prevention (QIEDC), Xining, China.
Wei Li*
National Institute for Communicable Disease Control and Prevention (ICDC), China CDC, Changping, Beijing, China.++State Key Laboratory of Infectious Disease Prevention and Control. Beijing, China
National Institute for Communicable Disease Control and Prevention (ICDC), China CDC, Changping, Beijing, China.++State Key Laboratory of Infectious Disease Prevention and Control. Beijing, China

# contributed equally to this work, * Corresponding author

Abstract

Following Clinical and Laboratory Standards Institute (CLSI) recommendations, the susceptibilities of twelve traditional or new recommended antimicrobial agents were evaluated by the agar microdilution method in 1012 strains of Yersinia pestis isolated from 1943 to 2017 in 12 natural plague foci in China. A clinical Y.pestis isolate (S19960127) isolated from a pneumonic plague outbreak in 1996 in Tibet Autonomous Region exhibited high-level resistance to streptomycin (the MIC was 4,096 mg/L). The strain S19960127 was still sensitive to other eleven antibiotics, i.e. ciprofloxacin, ofloxacin, kanamycin, chloramphenicol, ampicillin, ceftriaxone, cefuroxime, trimethoprim-sulfamethoxazole, tetracycline, spectinomycin and moxifloxacin. The remaining 1011 Y.pestis strains in this study demonstrated susceptibility to above mentioned twelve antimicrobial agents. Streptomycin is used as the first-line antibiotic against plague in many countries include China, thus antimicrobial sensitivity surveillance of Y.pestis isolates, including dynamically monitoring streptomycin resistant during various clinical plague treatment should be carried out routinely.

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Keywords
Yersinia pestis ;  Antimicrobial Susceptibility ;  Streptomycin ;  China
Subject Area
Pharmacology & Taxicology
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  • 23 Jun 2022 16:43 Version 3
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