Lower vitamin D level is associated with higher prevalence of Toxoplasma gondii infection – a national survey study

Preprint | 
10.55415/deep-2022-0029.v1
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Jiaofeng Huang
Department of Hepatology, Hepatology Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China, 350005++Fujian Clinical Research Center for Liver and Intestinal Diseases, Fujian, Fuzhou 350001, China
Department of Hepatology, Hepatology Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China, 350005++Fujian Clinical Research Center for Liver and Intestinal Diseases, Fujian, Fuzhou 350001, China
Yinlian Wu
Department of Hepatology, Hepatology Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China, 350005++Fujian Clinical Research Center for Liver and Intestinal Diseases, Fujian, Fuzhou 350001, China
Department of Hepatology, Hepatology Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China, 350005++Fujian Clinical Research Center for Liver and Intestinal Diseases, Fujian, Fuzhou 350001, China
Mingfang Wang
Department of Hepatology, Hepatology Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China, 350005++Fujian Clinical Research Center for Liver and Intestinal Diseases, Fujian, Fuzhou 350001, China
Department of Hepatology, Hepatology Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China, 350005++Fujian Clinical Research Center for Liver and Intestinal Diseases, Fujian, Fuzhou 350001, China
Yueyong Zhu
Department of Hepatology, Hepatology Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China, 350005++Fujian Clinical Research Center for Liver and Intestinal Diseases, Fujian, Fuzhou 350001, China
Department of Hepatology, Hepatology Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China, 350005++Fujian Clinical Research Center for Liver and Intestinal Diseases, Fujian, Fuzhou 350001, China
Su Lin*
Department of Hepatology, Hepatology Research Institute, the First Affiliated Hospital, Fujian Medical University, No. 20, Chazhong Road, Taijiang District, Fuzhou, Fujian, 350005, China.
Department of Hepatology, Hepatology Research Institute, the First Affiliated Hospital, Fujian Medical University, No. 20, Chazhong Road, Taijiang District, Fuzhou, Fujian, 350005, China.

# contributed equally to this work, * Corresponding author

Abstract

Objective: Vitamin D deficiency has been found to be associated with a high susceptibility to infections. The present study was to explore the relationship between vitamin D and Toxoplasma gondii (T. gondii) infection based on a nationally representative database. 

Methods: The study data came from the National Health and Nutrition Examination Surveys (NHANES) 2001-2004. Participants under 50 years old received both toxoplasma antibody test and serum vitamin D level test. The multivariate logistic regression and the propensity score matching methods were used to adjust potential confounders. All analysis was conducted by R 3.6.2. 

Results: A total of 10613 participants were included in this study, among them 3973 (37.4%) were diagnosed with vitamin D deficiency and 2070 (19.5%) were positive in T. gondii antibody (seropositive group). Vitamin D deficiency was found in 42.3% of the seropositive group, compared to 36.3% in seronegative group (P<0.001). After adjusted for sex, age, body mass index, smoking history, drinking history and testing season, vitamin D deficiency was associated with higher risk of T. gondii infection rate (OR=1.303, 95% CI=1.136–1.495, P<0.001). This result persisted in the propensity matched cohort. 

Conclusions: Low serum vitamin D level is associated with higher seroprevalence of toxoplasmosis in American population aged < 50.

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Supplementary Material
  1. tables.pdf
  2. Vitamin D and Toxoplasma gondii1.jpg
  3. Vitamin D and Toxoplasma gondii2.jpg
Keywords
Zoonoses ;  Parasitic diseases ;  Pathogen ;  Toxoplasma
Subject Area
General Medical Research ;  Nutrition
Version History
  • 27 May 2022 12:24 Version 1
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