Atrial fibrillation (AF) is a common complication of coronary revascularization operation. Currently, the mechanisms of postoperative AF are still unclear. This study aims to investigate the risk factors for new-onset AF (NOAF) post coronary revascularization operation and explore the early warning effect of clinical inflammatory markers. A retrospective analysis was conducted on 293 patients with unstable angina pectoris who underwent coronary artery revascularization operation in Beijing Chao-Yang Hospital, Capital Medical University, from April 2018 to June 2021, including 224 patients who underwent coronary artery bypass grafting and 69 patients who underwent one-step hybrid coronary revascularization. Baseline data, clinical data, blood indicators and AF episodes within 7 days post operation were collected. We divided the subjects into two groups according to whether AF occurred or not, and analyzed the data of two groups. Also, multivariate logistic regression was used to explore the independent risk factors for developing AF post coronary revascularization. In conclusion, aging, increased inferior-superior diameter of left atrial, use of intra-aortic balloon pump, increased blood volumes transfused during perioperative period and increased value of monocyte to high-density lipoprotein ratio on postoperative day 1 were independent risk factors for high-risk occurrence of NOAF after coronary artery operation.