Lineage-specific DNA hypomethylation impacts on complex traits in Human

Preprint | 
10.55415/deep-2023-0054.v1
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Siqian Chen#
China Agricultural University
China Agricultural University
Ying Yu*
China Agricultural University
China Agricultural University

# contributed equally to this work, * Corresponding author

Abstract

The cross-species characterization of evolutionary changes in the functional genome can facilitate the translation of genetic findings across species and the interpretation of the evolutionary basis underlying complex phenotypes. A better understanding of the evolutionary divergence in DNA methylation in humans will enable us to unveil the regulatory mechanisms underlying humans-specific molecular and complex phenotypes.

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Keywords
human evolution ;  DNA hypomethylation ;  GWAS enrichment
Subject Area
Evolutionary Biology
Version History
  • 15 Oct 2023 20:13 Version 1
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