The emerging role of HJURP as a therapeutic target in cancers

Preprint | 
10.55415/deep-2023-0031.v1
This is not the most recent version. There is anewer versionof this content available.
Jiaqi Tan
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, P.R. China++Huachiew Traditional Chinese Medicine Clinic, Thailand
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, P.R. China++Huachiew Traditional Chinese Medicine Clinic, Thailand
Lertnimitphun Peeraphong
Huachiew Traditional Chinese Medicine Clinic, Thailand
Huachiew Traditional Chinese Medicine Clinic, Thailand
Chattarin Ruchawapol
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, P.R. China++Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, P.R. China
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, P.R. China++Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, P.R. China
Juan Zhang
School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
Juan Zhao
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, P.R. China
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, P.R. China
Wen-Wei Fu
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, P.R. China++Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, P.R. China
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, P.R. China++Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, P.R. China
Li Zhang*
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, P.R. China++Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, P.R. China
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, P.R. China++Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, P.R. China
Hong-Xi Xu*
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, P.R. China++Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, P.R. China
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, P.R. China++Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, P.R. China

# contributed equally to this work, * Corresponding author

Abstract

Holliday junction recognition protein (HJURP) is a key molecular chaperone for centromere protein A (CENP-A), which is essential for chromosome separation during mitosis and cell cycle regulation. Recent studies have identified the essential role of HJURP in carcinogenesis. Abnormal upregulation of HJURP expression has been observed in various human cancers, such as non-small cell lung cancer (NSCLC), hepatocellular carcinoma (HCC), bladder cancer, and breast cancer, which is associated with poor pathological development and prognosis. In vitro and in vivo studies have shown that HJURP exerts oncogenic functions mainly by regulating the cell cycle, cellular senescence, and epithelial-mesenchymal transition (EMT). This review aims to evaluate the prognostic significance of HJURP in human cancers and summarize antitumor studies targeting HJURP. The effects and regulatory factors of HJURP in carcinogenesis have also been discussed to provide new insights into targeting HJURP as a promising strategy for cancer treatment.

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Keywords
HJURP ;  prognosis ;  carcinogenesis ;  cell cycle
Subject Area
Cancer Biology
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Version History
  • 04 May 2023 22:34 Version 1
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