Supplementary Material
Establishment of a protein thermal shift chip (PTSC) for COVID-19：exploring the future of protein chip in pharmacology
Preprint |
10.55415/deep-2022-0039.v1
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Abstract
The traditional protein chip based on a solid chip is impossible to provide drug and target screening in a label-free manner. Here, the concept of protein thermal stability chip (PTSC) was proposed based on fluorescence signal and has characteristics including low cost, high throughput, and label-free. The PTSC for COVID-19 contains twelve targets from SARS-CoV-2 and host. Series of quality control tests have been carried out for small molecule drugs, macromolecular antibody, and herbal medicine extracts. This chip can achieve a high-throughput screening of COVID-19 drugs, and provide a tool for screening the drug target of clinically effective drugs.
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- 20 Jul 2022 11:41 Version 1
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