Structure Prediction of the whole Proteome of Monkeypox variants
# contributed equally to this work, * Corresponding author
Abstract
Recently, the monkeypox virus has begun to spread in many countries worldwide. The genome sequence of the monkeypox virus, associated with the current variant leading to an outbreak, was reported. It is important to better understand the new variant for accelerating the development of vaccines and drugs. Here, we reported the structure predictions of the whole proteomes of the three monkeypox variants and annotated the potential small molecule binding regions of the proteins. Meanwhile, experimentally determined structures with high similarity to monkeypox proteins are vetted through structure-alignment algorithm. Our work would help to accelerate the development of vaccines and drugs.
- 15 Jun 2022 22:20 Version 1
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